The Cincinnati Bearcats (3-1) play a conference opponent when they host the No. 14 Iowa State Cyclones (5-0) on Saturday, October 4, 2025 at Nippert Stadium in a Big 12 showdown.

Watch college football live without cable. Stream ACC, SEC, ESPN and more with Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and start watching college football games now.

Cincinnati vs. Iowa State Matchup Info

Game date: Saturday, October 4, 2025
Game time: 12 p.m. ET
Location: Cincinnati, Ohio
Venue: Nippert Stadium
TV channel: ESPN2
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Stop missing games and start streaming college football right now on Fubo.

Cincinnati vs. Iowa State Odds and Prediction

Spread favorite: Bearcats (-1.5)
Moneyline: Bearcats (-123), Cyclones (+104)
Total: 55.5 points
Pick ATS: Iowa State (+1.5)
Pick OU: Under (55.5)
Prediction: Iowa State 25, Cincinnati 24

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

Looking for officially licensed gear? Fanatics has jerseys, hats, apparel, memorabilia, trading cards, collectibles and more.

Cincinnati vs. Iowa State Betting Records and Insights

Cincinnati has put together a 3-1-0 record against the spread this season.
Iowa State has compiled a 3-1-1 record against the spread this season.
The Bearcats have covered the spread once when favored by 1.5 points or more this season (in two opportunities).
The Cyclones have been an underdog by 1.5 points or more once this season, and covered the spread.
In Cincinnati's four games this season, the combined scoring has gone over the point total three times.
So far this season, two Iowa State games have hit the over.

The Jason Smith Show with Mike Harmon