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The Cleveland Cavaliers (0-0) are just 2.5-point underdogs against the Philadelphia 76ers (1-0) at Xfinity Mobile Arena on Thursday, October 22, 2026. The game tips at 7 p.m. ET on ESPN.
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Listen to the game on Newsradio WTAM 1100
Cavaliers vs. 76ers Predictions for Thursday
Our computer projections model for this encounter expects a final score of Cavaliers 116, 76ers 115.
- Moneyline Pick: Cavaliers (+121)
- Total Pick: Under 236.5 (computer predicts 230.9 points)
- Pick ATS: Cavaliers (+2.5)
Recent Cavaliers vs. 76ers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 3/9/2026 | Cavaliers | -13.5 | 226.5 | -877 | +592 | 115-101 CLE |
| 1/16/2026 | 76ers | -2.5 | 233 | -139 | +117 | 117-115 CLE |
| 1/14/2026 | Cavaliers | -1.5 | 236.5 | -105 | -114 | 133-107 CLE |
| 11/5/2025 | Cavaliers | -10.5 | 235.5 | -483 | +368 | 132-121 CLE |
76ers 2025-26 Betting Trends
- Against the spread, Philadelphia was 41-41-0 last season.
- Against the spread, as 2.5-point favorites or greater, the 76ers went 22-12 last year.
- Of Philadelphia's 82 games last season, 41 hit the over.
- The 76ers won 34 of the 46 games they were listed as the moneyline favorite last season (73.9%).
- When it played as a moneyline favorite with odds of -144 or shorter last year, Philadelphia finished with a record of 27-3 (90%).
Cavaliers 2025-26 Betting Trends
- Cleveland covered 34 times in 82 chances against the spread last year.
- The Cavaliers had an ATS record of 7-5 as underdogs of 2.5 points or greater last year.
- In Cleveland's games last year, the combined scoring went over the point total 40 times.
- The Cavaliers were underdogs in 16 games last season and won seven (43.8%) of those contests.
- Cleveland had a record of 3-5 when it was set as the underdog by +121 or more by oddsmakers last season.
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Cavaliers vs. 76ers Injury Report
76ers
76ers:
Dominick Barlow: Out (Back),
Tacko Fall: Out (Hip),
Dean Wade: Questionable (Ankle),
Ariel Hukporti: Out For Season (Achilles)
Cavaliers
Cavaliers:
Nae'Qwan Tomlin: Out (Back),
Khalifa Diop: Out (Knee),
Jarrett Allen: Questionable (Patellar)
Cavaliers vs. 76ers Game Time and TV Channel
- Game day: Thursday, October 22, 2026
- Game time: 7 p.m. ET
- TV channel: ESPN
- Location: Philadelphia, Pennsylvania
- Arena: Xfinity Mobile Arena
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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