Photo: Thien-An Truong / Getty Images Sport / Getty Images
According to our computer projections, the San Francisco 49ers will take down the Cleveland Browns when the two teams come together at Huntington Bank Field on Sunday, Nov. 30, which kicks off at 1 p.m. ET. For our predictions on the spead, point total, and final score, see the rest of the article below.
Don't miss a touchdown this NFL season. Catch every score with NFL RedZone on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and watch seven hours of football from every NFL game every Sunday.
49ers vs. Browns Game Info and TV Channel
- When: Sunday, November 30, 2025 at 1 p.m. ET
- Where: Huntington Bank Field in Cleveland, Ohio
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
Catch every NFL touchdown with NFL RedZone on Fubo.
Listen to the game on 107.7 The Bone
49ers vs. Browns Odds and Betting Info
- Spread favorite: 49ers (-5.5)
- Moneyline: 49ers (-253), Browns (+207)
- Total: 35.5 points
49ers vs. Browns Prediction
- Pick ATS: 49ers (-5.5)
- Pick OU: Over (35.5)
Prediction:
49ers 27 - Browns 15
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
See how these predictions pan out and sign up for NFL RedZone on Fubo to catch every score on Sundays this fall.
49ers vs. Browns Betting Insights
- The 49ers have covered seven times in 12 matchups with a spread this season.
- The Browns have won five games against the spread this year, failing to cover six times.
- San Francisco has covered the spread when playing as at least 5.5-point favorites in their only opportunity this season.
- Cleveland has covered the spread twice as an underdog by 5.5 points or more this season (in six opportunities).
- In the 49ers' 12 games this season, the combined scoring has gone over the point total seven times.
- So far this year, six out of the Browns' 11 games with a set over/under have gone over the point total.
Looking for NFL tickets? Head to StubHub today and see your team live.